کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3050409 | 1579861 | 2010 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats](/preview/png/3050409.png)
Individuals with epilepsy often complain about memory deficits. Various synthetic derivatives of natural flavonoids are known to have neuroactive properties. Rutin is a flavonoid that is an important dietary constituent of foods and plant-based beverages. The aim of the present study was to investigate the effects of rutin on memory retrieval in pentylenetetrazole (PTZ)-kindled rats using a step-through passive avoidance task. We administered rutin and PTZ intraperitoneally every other day prior to the start of training. Two retention tests were subsequently performed to assess memory in these rats. The results suggest that pretreatment with rutin at 50 and 100 mg/kg can attenuate seizure severity during the kindling procedure. Furthermore, rutin administration significantly increased the step-through latency in the passive avoidance paradigm. Taken together, these results indicate that rutin has a potential role in enhancing memory retrieval in kindled rats.
Journal: Epilepsy & Behavior - Volume 18, Issues 1–2, May 2010, Pages 50–53