کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3053639 1580011 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Febrile seizures in children with familial Mediterranean fever: Coincidence or association?
ترجمه فارسی عنوان
تشنج های فوری در کودکان مبتلا به تب مداخله خانوادگی: بروز یا ترکیب؟
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی


• We questioned the link between febrile seizures and FMF.
• The frequency of febrile seizure was higher in children with FMF.
• High rates may be related to fever during FMF attacks in susceptible individuals.
• It may also be a neurologic complication of FMF.

BackgroundFamilial Mediterranean fever (FMF) is an inherited disease characterized by recurrent bouts of fever and polyserositis and caused by MEditerranean FeVer gene (MEFV) mutations. Given the febrile characteristics of the disease one would expect higher frequency of febrile seizure in this group of pediatric patients.ObjectivesTo evaluate the frequency of febrile seizure and related factors in patients with FMF.MethodsThe children with the diagnosis of FMF were enrolled in the study. Information including clinical features, type of mutation and the history of febrile seizure were all noted.ResultsA total of 97 patients, 43 (44.3%) girls with a median age of 7.93 ± 4.05 years (2–16) and a median follow-up period of 20.65 ± 24.33 months (6–135) were included in the study. The frequency of febrile seizure in children with FMF was found as 13.4%, which is higher than the general population [p = 0.04, OR: 2.9 (95% CI: 1.0–8.5)]. The allele frequency of exon 2 mutations in MEFV genes was higher in the patients with febrile seizure (p = 0.03). Frequency of FMF related clinical findings (fever, abdominal pain, arthralgia/myalgia, arthritis, chest pain and erysipelas-like erythema) was similar between the two groups. However, frequency of headache was higher in the patients with febrile seizure (p = 0.014).ConclusionThe frequency of febrile seizure in children with FMF was found to be higher than the general population. Although this finding may be related to high fever during FMF attacks in individuals with genetic propensity of febrile seizure, it may also be a neurologic complication of FMF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Paediatric Neurology - Volume 19, Issue 5, September 2015, Pages 572–576
نویسندگان
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