کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3055838 1186542 2010 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cholesterol and statins in Alzheimer's disease: Current controversies
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Cholesterol and statins in Alzheimer's disease: Current controversies
چکیده انگلیسی

Alzheimer's disease (AD) is the principal cause of dementia in older people, and accumulation of amyloid-beta (Aβ) peptide is a crucial event in AD pathogenesis. Despite opposite results found in literature, increased evidence posits that high cholesterol levels enhance the risk to develop AD. In fact, cholesterol metabolism and catabolism are affected in this neurodegenerative disorder. Since amyloid precursor protein (APP) processing and subsequent Aβ production are dependent on membrane cholesterol content and on levels of isoprenoid intermediates in the cholesterol biosynthesis pathway, changes in cholesterol might have different consequences on Aβ formation. These pieces of evidence support that inhibitors of cholesterol synthesis, like statins, could have a therapeutic role in AD. Many studies about the effect of statins use in AD show conflicting results; however, some authors explain it by the differences in administrated doses. Recent studies demonstrate that statins can efficiently decrease Aβ formation from APP and be neuroprotective against the peptide toxicity. Because of the high number of pleiotropic effects of statins, novel molecular mechanisms that account for the beneficial effect of these drugs on AD might be discovered in a near future.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 223, Issue 2, June 2010, Pages 282–293
نویسندگان
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