کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3055881 1186542 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration
چکیده انگلیسی

Environmental exposures suspected of contributing to the pathophysiology of Parkinson's disease (PD) include potentially neurotoxic pesticides, which have been linked to an increased risk of PD. Conversely, possible protective factors such as the adenosine antagonist caffeine have been linked to a reduced risk of the disease. Here we assessed whether caffeine alters dopaminergic neuron loss induced by exposure to environmentally relevant pesticides (paraquat and maneb) over 8 weeks. The number of nigral neurons positive for tyrosine hydroxylase immunoreactivity (TH+) was assessed using stereological methods and found to be significantly reduced (to 60% of control) by combined pesticide treatment. Caffeine at 20 mg/kg significantly reduced TH+ neuron loss (to 85% of the respective control). The results demonstrate the neuroprotective potential of caffeine in a chronic pesticide exposure model of model of PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 223, Issue 2, June 2010, Pages 657–661
نویسندگان
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