کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3056914 1186581 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pain behaviors after spinal cord contusion injury in two commonly used mouse strains
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Pain behaviors after spinal cord contusion injury in two commonly used mouse strains
چکیده انگلیسی

We have characterized spontaneous and evoked pain behaviors that develop in a model of severe spinal contusion injury using two commonly used strains of mice. Using the Infinite Horizon Tissue Impactor to produce these contusion injuries, we were able to set strict limits on the injury parameters (i.e., force of impact and tissue displacement). This helps to generate a uniform population of spinal cord injury severity and allows for meaningful comparisons to be made across the two strains of mice. After contusion injury, strain differences were apparent in several injury-evoked behaviors such as hindlimb spasticity, spontaneous caudally directed nociceptive behaviors and over-grooming. Similar to the anatomical rearrangements observed in the rat after spinal cord injury, we observed significant changes in sensory innervation of the dorsal horn in both strains. In addition, there was increased expression of protein kinase C gamma (PKCγ) in cells outside of the inner region of lamina II (IIi) in both strains after spinal contusion injury. However, the magnitude and intensity of this increase was more pronounced in BALB/c mice. PKCγ is an important mediator of persistent pain behaviors after peripheral nerve injury and inflammation. Our results suggest that PKCγ may also contribute to neuropathic pain behaviors after direct lesion to the spinal cord.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 206, Issue 2, August 2007, Pages 240–247
نویسندگان
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