کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3057203 1186591 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats
چکیده انگلیسی

In the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB1R), which has been shown to control several brain functions affected by diabetes, such as synaptic plasticity, glucose utilisation, memory consolidation and cognition, and maturation and survival of hippocampal neurons. However, the role of this receptor has not been investigated yet in diabetic encephalopathy. We report now that in the streptozotocin animal model of T1D, the hippocampal densities of CB1R protein and of specific CB1R binding sites are significantly increased both in the nerve terminals and in total membranes (changes between 13% and 38%), whereas CB1R mRNA expression is decreased by 25%, suggesting that CB1Rs might play a role in diabetic encephalopathy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 204, Issue 1, March 2007, Pages 479–484
نویسندگان
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