کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3062809 | 1187499 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MicroRNA expression changes in the hippocampi of rats subjected to global ischemia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
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چکیده انگلیسی
The hippocampus is particularly vulnerable to ischemia, which is accompanied by substantial alterations in gene expression. Recent studies show that microRNAs extensively mediate post-transcriptional gene expression. However, the regulatory mechanisms in the hippocampus that microRNAs participate in remain unclear. Here, we used microarray analysis to characterize the microRNA expression profile in rat hippocampus and to identify changes in expression after 20Â minutes of global ischemia followed by either 30Â minutes or 24Â hours of reperfusion. In the normal hippocampus, we detected 286 microRNAs, of which the let-7 family accounted for 32%. After ischemia followed by 30Â minutes of reperfusion, 23 microRNAs were upregulated and 32 were downregulated; after 24Â hours of reperfusion 40 were upregulated and 31 were downregulated. These results suggest that several microRNAs may be involved in regulating the normal physiological activity of the hippocampus and its response to ischemia and reperfusion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 17, Issue 6, June 2010, Pages 774-778
Journal: Journal of Clinical Neuroscience - Volume 17, Issue 6, June 2010, Pages 774-778
نویسندگان
Yuan Yuan, Jin Ye Wang, Luo Yi Xu, Rong Cai, Zhi Chen, Ben Yan Luo,