کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064201 1580408 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vaccine efficacy of transcutaneous immunization with amyloid β using a dissolving microneedle array in a mouse model of Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Vaccine efficacy of transcutaneous immunization with amyloid β using a dissolving microneedle array in a mouse model of Alzheimer's disease
چکیده انگلیسی


• We examined vaccine efficacy of transcutaneous immunization for Alzheimer’s disease.
• Transcutaneous immunization using MicroHyala induced anti-Aβ1–42 immune responses.
• Our system may contribute to simple and easy-to-use vaccine for Alzheimer’s disease.

Vaccine therapy for Alzheimer's disease (AD) based on the amyloid cascade hypothesis has recently attracted attention for treating AD. Injectable immunization using amyloid β peptide (Aβ) comprising 1–42 amino-acid residues (Aβ1–42) as antigens showed therapeutic efficacy in mice; however, the clinical trial of this injected Aβ1–42 vaccine was stopped due to the incidence of meningoencephalitis caused by excess activation of Th1 cells infiltrating the brain as a serious adverse reaction. Because recent studies have suggested that transcutaneous immunization (TCI) is likely to elicit Th2-dominant immune responses, TCI is expected to be effective in treating AD without inducing adverse reactions. Previously reported TCI procedures employed complicated and impractical vaccination procedures; therefore, a simple, easy-to-use, and novel TCI approach needs to be established. In this study, we investigated the vaccine efficacy of an Aβ1–42-containing TCI using our novel dissolving microneedle array (MicroHyala; MH) against AD. MH-based TCI induced anti-Aβ1–42 immune responses by simple and low-invasive application of Aβ1–42-containing MH to the skin. Unfortunately, this TCI system resulted in little significant improvement in cognitive function and Th2-dominant immune responses, suggesting the need for further modification.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 266, Issues 1–2, 15 January 2014, Pages 1–11
نویسندگان
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