کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064294 1580418 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis
چکیده انگلیسی

Growing evidence has demonstrated that dysfunction of follicular helper T (TFH) cells results in an abnormal positive selection of autoreactive B cells, which contributes to the development of autoimmune diseases. This study reveals that the frequency of circulating counterparts of TFH cells in myasthenia gravis (MG) patients is significantly higher compared to healthy controls. Interestingly, the frequencies of circulating TFH cells were positively correlated with the levels of serum anti-AChR Ab in MG patients. Our data suggest the presence of overactivation and expansion of circulating counterparts of TFH cells in MG patients, which may contribute to the immunopathogenesis of MG.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 256, Issues 1–2, 15 March 2013, Pages 55–61
نویسندگان
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