کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064691 1580453 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis
چکیده انگلیسی

BackgroundPlasma and B cells are implicated in multiple sclerosis (MS) and produce free light chains (FLC) that are excreted in urine.ObjectiveTo confirm that demyelinating diseases (DD) cause increased urinary FLCs.MethodUrinary FLC in 50 patients with DD were compared to 20 patients with posterior uveitis (PU), 19 with AIDS, 34 with rheumatoid arthritis (RA) and 19 normal controls (NC).ResultSubjects with DD, PU, RA and AIDS have higher urinary FLCs than NC (p < 0.01). Urinary FLCs did not correlate with gadolinium-enhancing lesions on MRI.ConclusionsUrinary FLCs are raised in DD. Further studies are required to see if they correlate with disease activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 220, Issues 1–2, 30 March 2010, Pages 99–103
نویسندگان
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