کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065008 | 1580459 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Candidate biomarkers of chronic inflammatory demyelinating polyneuropathy (CIDP): Proteome analysis of cerebrospinal fluid
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
We aimed to identify disease-related biomarkers in CIDP. Using the two-dimensional difference in gel electrophoresis (2-D-DIGE), we compared CSF from patients with CIDP (n = 11) and controls (n = 11). Protein spots that showed a significant difference were further analyzed by MALDI-TOF mass spectrometry. We identified 10 proteins that were upregulated in CIDP (two transferrin isoforms, alpha-1 acid glycoprotein 1 precursor, apolipoprotein A IV, two haptoglobin isoforms, transthyretin (TTR), retinol binding protein and two isoforms of proapolipoprotein) and 1 protein that was downregulated (integrin beta 8). The pathophysiological role of these proteins remains to be clarified by further studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 214, Issues 1–2, 29 September 2009, Pages 109–112
Journal: Journal of Neuroimmunology - Volume 214, Issues 1–2, 29 September 2009, Pages 109–112
نویسندگان
Hayrettin Tumani, Martin Pfeifle, Vera Lehmensiek, Daniela Rau, Helga Mogel, Albert C. Ludolph, Johannes Brettschneider,