کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065008 1580459 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Candidate biomarkers of chronic inflammatory demyelinating polyneuropathy (CIDP): Proteome analysis of cerebrospinal fluid
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Candidate biomarkers of chronic inflammatory demyelinating polyneuropathy (CIDP): Proteome analysis of cerebrospinal fluid
چکیده انگلیسی

We aimed to identify disease-related biomarkers in CIDP. Using the two-dimensional difference in gel electrophoresis (2-D-DIGE), we compared CSF from patients with CIDP (n = 11) and controls (n = 11). Protein spots that showed a significant difference were further analyzed by MALDI-TOF mass spectrometry. We identified 10 proteins that were upregulated in CIDP (two transferrin isoforms, alpha-1 acid glycoprotein 1 precursor, apolipoprotein A IV, two haptoglobin isoforms, transthyretin (TTR), retinol binding protein and two isoforms of proapolipoprotein) and 1 protein that was downregulated (integrin beta 8). The pathophysiological role of these proteins remains to be clarified by further studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 214, Issues 1–2, 29 September 2009, Pages 109–112
نویسندگان
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