کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065478 | 1580481 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Hypothermia suppresses inflammation via ERK signaling pathway in stimulated microglial cells Hypothermia suppresses inflammation via ERK signaling pathway in stimulated microglial cells](/preview/png/3065478.png)
Hypothermic perfusion is a standard method for neuroprotection during cardiac surgery in children. However, the cellular responses underlying these mechanisms have not been clearly elucidated.In the present study we demonstrated that the inflammatory response of stimulated microglial cells is significantly reduced after moderate hypothermia.Continuous hypothermia caused a diminished NO release. Moderate hypothermia and rewarming caused a downregulation of phosphorylated MEK, ERK and iNOS-expression, diminished cytokine release and reduced CD-11a and ICAM-1 expression. Thus, neuroprotection offered by hypothermia could be attributed to reduced cytotoxic products released from stimulated microglial cells mediated by the MEK/ERK signal transduction pathway.
Journal: Journal of Neuroimmunology - Volume 189, Issues 1–2, September 2007, Pages 7–16