کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065607 1580484 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of chronic nicotine on sciatic nerve injury in the rat
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Impact of chronic nicotine on sciatic nerve injury in the rat
چکیده انگلیسی

Chronic nicotine exposure and the immune response to peripheral nerve injury has not been investigated thoroughly. Rats were exposed to chronic nicotine or saline followed by chronic constriction injury (CCI) of the sciatic nerve. Mechanical sensitivity was measured at various time points and the immune response was investigated at 21 days post-CCI. Chronic nicotine increased mechanical hypersensitivity, microglia activation, and the production of IL-1β, but not the number of immune cells at the site of injury. These results suggest that chronic nicotine increases mechanical hypersensitivity following peripheral nerve injury through a mechanism that may involve an increased production and release of central and peripheral cytokines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 186, Issues 1–2, May 2007, Pages 37–44
نویسندگان
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