کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3069271 1580643 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Subthalamic nucleus high-frequency stimulation modulates neuronal reactivity to cocaine within the reward circuit
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Subthalamic nucleus high-frequency stimulation modulates neuronal reactivity to cocaine within the reward circuit
چکیده انگلیسی


• We analyze if STN HFS interferes with reactivity to cocaine in the reward circuit.
• STN HFS alone increases c-Fos only in the GP and the BLA.
• STN HFS inhibits the c-Fos response induced by acute cocaine in the striatum.
• catFISH analysis highlights the complex regulation of c-Fos and Arc under STN HFS.
• Decreased reactivity to cocaine may explain its decreased rewarding properties under STN HFS.

The subthalamic nucleus (STN) is a critical component of a complex network controlling motor, associative and limbic functions. High-frequency stimulation (HFS) of the STN is an effective therapy for motor symptoms in Parkinsonian patients and can also reduce their treatment-induced addictive behaviors. Preclinical studies have shown that STN HFS decreases motivation for cocaine while increasing that for food, highlighting its influence on rewarding and motivational circuits. However, the cellular substrates of these effects remain unknown. Our objectives were to characterize the cellular consequences of STN HFS with a special focus on limbic structures and to elucidate how STN HFS may interfere with acute cocaine effects in these brain areas. Male Long–Evans rats were subjected to STN HFS (130Hz, 60 μs, 50–150 μA) for 30 min before an acute cocaine injection (15 mg/kg) and sacrificed 10 min following the injection. Neuronal reactivity was analyzed through the expression of two immediate early genes (Arc and c-Fos) to decipher cellular responses to STN HFS and cocaine. STN HFS only activated c-Fos in the globus pallidus and the basolateral amygdala, highlighting a possible role on emotional processes via the amygdala, with a limited effect by itself in other structures. Interestingly, and despite some differential effects on Arc and c-Fos expression, STN HFS diminished the c-Fos response induced by acute cocaine in the striatum. By preventing the cellular effect of cocaine in the striatum, STN HFS might thus decrease the reinforcing properties of the drug, which is in line with the inhibitory effect of STN HFS on the rewarding and reinforcing properties of cocaine

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 80, August 2015, Pages 54–62
نویسندگان
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