کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3069369 1580667 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene–environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Gene–environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models
چکیده انگلیسی

Interactions between genetic factors and environmental exposures are thought to be major contributors to the etiology of Parkinson's disease. While such interactions are poorly defined and incompletely understood, recent epidemiological studies have identified specific interactions of potential importance to human PD. In this review, the most current data on gene–environment interactions in PD from human studies are critically discussed. Animal models have also highlighted the importance of genetic susceptibility to toxicant exposure and data of potential relevance to human PD are discussed. Goals and needs for the future of the field are proposed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 57, September 2013, Pages 38–46
نویسندگان
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