The A1 receptor agonist R-Pia reduces the imbalance between cerebral glucose metabolism and blood flow during status epilepticus: Could this mechanism be involved with neuroprotection?

►R-Pia reduces the “mismatch” between cerebral glucose consumption and blood flow during seizures induced by pilocarpine. ►R-Pia protects rat brain against excitotoxicity caused by status epilepticus. ►Reduction in the excessive consumption of cerebral glucose was observed in rats receiving pilocarpine following R-Pia.