کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3069833 1580702 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease
چکیده انگلیسی

Parkinson's disease has been found to be caused by both, genetic and environmental factors. Despite the diversity of causes involved, a convergent pathogenic mechanism might underlie the special vulnerability of dopaminergic neurons in different forms of Parkinsonism. In recent years, a number of reports have proposed dopamine as a common player responsible in the loss of dopaminergic neurons independent of its etiology. Using RNAi lines we were able to generate flies with drastically reduced dopamine levels in the dopaminergic neurons. Combining these flies with a chemically induced Parkinson model (rotenone) and a familial form of Parkinson (mutant α-synuclein) we were able to show a strong reduction of neurotoxicity and a protection of the dopaminergic neurons when cellular dopamine levels were reduced. These results show that dopamine homeostasis plays a central role for the susceptibility of dopaminergic neurons to environmental and genetic factors in in vivo models of Parkinson disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 40, Issue 1, October 2010, Pages 113–119
نویسندگان
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