کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3070097 | 1580719 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased levels of cocaine and amphetamine regulated transcript in two animal models of depression and anxiety
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Increased levels of cocaine and amphetamine regulated transcript in two animal models of depression and anxiety Increased levels of cocaine and amphetamine regulated transcript in two animal models of depression and anxiety](/preview/png/3070097.png)
چکیده انگلیسی
The neurobiological bases of mood disorders remain elusive but both monoamines and neuropeptides may play important roles. The neuropeptide cocaine and amphetamine regulated transcript (CART) was shown to induce anxiety-like behavior in rodents, and mutations in the human CART gene are associated with depression and anxiety. We measured CART-like immunoreactivity (-LI) in genetic rat models of depression and anxiety, i.e. the Flinders Sensitive Line (FSL) and rats selected for High Anxiety-related Behavior (HAB) using a radioimmunoassay. CART-LI was significantly increased in the periaqueductal grey in FSL rats, whereas in the HAB strain it was increased in the hypothalamus, both compared with their respective controls. No line-dependent changes were found in the hippocampus, striatum or frontal cortex. Our results confirm human genetic studies indicating CART as a neurobiological correlate of depression and anxiety, and suggest that its differential regulation in specific brain regions may play a role for the behavioral phenotypes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 34, Issue 2, May 2009, Pages 375-380
Journal: Neurobiology of Disease - Volume 34, Issue 2, May 2009, Pages 375-380
نویسندگان
Sara Wiehager, Daniela I. Beiderbeck, Susanne H.M. Gruber, Aram El-Khoury, Jackie Wamsteeker, Inga D. Neumann, Ã
sa Petersén, Aleksander A. Mathé,