کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3083916 1581178 2012 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Temozolomide and Other Potential Agents for the Treatment of Glioblastoma Multiforme
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مغز و اعصاب بالینی
پیش نمایش صفحه اول مقاله
Temozolomide and Other Potential Agents for the Treatment of Glioblastoma Multiforme
چکیده انگلیسی

This article provides historical and recent perspectives related to the use of temozolomide for the treatment of glioblastoma multiforme. Temozolomide has quickly become part of the standard of care for the modern treatment of stage IV glioblastoma multiforme since its approval in 2005. Yet despite its improvements from previous therapies, median survival remains approximately 15 months, with a 2-year survival rate of 8% to 26%. The mechanism of action of this chemotherapeutic agent, conferred advantages and limitations, treatment resistance and rescue, and potential targets of future research are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurosurgery Clinics of North America - Volume 23, Issue 2, April 2012, Pages 307–322
نویسندگان
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