La paralysie supranucléaire progressive

Progressive supranuclear palsy is one of the most frequent atypical parkinsonian syndromes. It is characterized by an axial parkinsonism associated with early postural instability and falls, vertical gaze palsy, and cognitive and behavioral impairments. There is currently no cure to the disease and patient management relies on often disappointing symptomatic treatments and physiotherapy. Death occurs 6 to 7 years after onset, usually following an injurious fall or a severe aspiration. Several clinical variants have recently been identified and a new nosology is emerging.