Mise au point sur la sclérose en plaques de début tardif : 10 questions portant sur la SEP du sujet âgé

Late-onset multiple sclerosis, defined as multiple sclerosis with symptom onset after the age of 50 years, is an often unrecognized, probably under-diagnosed clinical form of the disease. This nosological entity has been only recently described because some of its characteristics contrast with those of classical early-onset multiple sclerosis. It deserves to be better known. However, in this context, late-onset multiple sclerosis diagnosis should only be established after differential diagnoses more frequent after the age of 50 years have been ruled out. We propose in this article an update on this specific clinical form of multiple sclerosis, examining 10 questions about the underlying pathogenic mechanisms, the clinical presentation and course and therapeutic options.