کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3093987 | 1190550 | 2006 | 6 صفحه PDF | دانلود رایگان |
BackgroundTo investigate the effects of SES and geographic variations on survival for adult patients with glioma, we analyzed data from 30 489 patients from the Cancer Registry in England and Wales.MethodsMedian survival and CSRs for 8 variables (age, sex, morphology, World Health Organization [WHO] grade, tumor site, SES, geographic regions, and periods of diagnosis) are calculated using the Kaplan-Meier method. Distributions among different variables are compared using χ2 test. Cox regressions are performed for estimating HRs to death.ResultsThe median survival and the 1-, 5-, and 10-year CSR in this population are 0.42 years, 29.1%, 12.0%, and 7.7%, respectively. There is a gradient in SES from the south to the north (χ2 test, P < .001) and a gradual increment in higher SES from the early to the recent period (χ2 test, P < .001). Mono- and multivariate analyses reveal that all the 8 variables influenced the survival (P < .05). Age (HR, 1.04 per year from 15 years, P < .001), WHO grade (1.21 per grade from grade I, P < .001), and morphology (HR from 1.23 to 1.89, compared with ependymoma, P < .05) are the most influential factors. However, there are also independent effects from SES (HR, 1.03 per quintile of deprivation, P < .001) and geographic regions (HR, 1.10 for outside southern England; P < .001) on the survival.ConclusionsAlthough age and tumor characteristics (morphology, WHO grade, tumor site) are well-known prognostic factors, SES and geographic variations also play a slight but significant role, and for more cost-effective allocation of health resources, alleviation on these 2 modifiable factors should be considered.
Journal: Surgical Neurology - Volume 66, Issue 3, September 2006, Pages 258–263