کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3096330 1581480 2012 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolution and Future of Skull Base Surgery: The Paradigm of Skull Base Meningiomas
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Evolution and Future of Skull Base Surgery: The Paradigm of Skull Base Meningiomas
چکیده انگلیسی

BackgroundSkull base meningiomas represent the paradigm for the evolution of skull base surgery within the past 50 years into a distinct neurosurgical subspecialty.MethodsFrom 2005 to 2011, 117 patients with cranial base meningiomas underwent surgical resection. Extent of resection, histologic grade, complications, functional status, and recurrence-free and overall survival data are presented.ResultsThe summary rate of gross total resection was 53.0%. The surgical complication and mortality rates were 17.9% and 0.9%, respectively. Five-year recurrence-free survival was 88.0% for grade I meningiomas. A total of 90.3% of patients had a Karnofsky performance score ≥80 at last follow-up.ConclusionsA large contemporary series of skull base meningiomas is presented. In addition, the evolution of surgical approaches to skull base meningiomas is reviewed, together with the current issues regarding radiation therapy, management of cavernous sinus tumor, oncologic management of atypical and malignant subtypes, molecular genetics, and future therapeutic options.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: World Neurosurgery - Volume 78, Issues 3–4, September–October 2012, Pages 260–275
نویسندگان
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