کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3096395 1581478 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acute Normovolemic Hemodilution Is Safe in Neurosurgery
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Acute Normovolemic Hemodilution Is Safe in Neurosurgery
چکیده انگلیسی

ObjectiveTo determine the safety of acute normovolemic hemodilution (ANH) for patients undergoing neurosurgical procedures.MethodsA group of 100 patients undergoing neurosurgical procedures was assigned prospectively to receive ANH. A group of 47 patients who underwent craniotomy for aneurysm clipping and standard anesthetic management was used as a control. Procedures conducted under ANH were performed without significant variations in physiologic parameters.ResultsCompared with controls, intraoperative blood loss, operative time, incidence and grade of complications, and length of hospital stay were similar between the two groups. Although the ANH group showed a difference in prothrombin levels before and after hemodilution procedures, the levels were still considered within physiologic parameters. Platelet counts and partial thromboplastin time (PTT) levels indicated no significant variations in either group. During the ANH procedure, a considerable reduction of brain oxygen extraction was observed in individuals with worse preoperative neurologic status (P < 0.05), indicating potential benefit. Among patients with cerebral aneurysm, patients with good initial clinical grades had better clinical results as indicated by Glasgow Outcome Scale scores (P < 0.02).ConclusionsANH is a safe procedure for patients undergoing neurosurgical procedures. Further studies are necessary to confirm the improvement in brain oxygen extraction and the clinical impact. Nonetheless, patients undergoing aneurysm clipping with good clinical grades seem to profit from ANH.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: World Neurosurgery - Volume 79, Issues 5–6, May–June 2013, Pages 719–724
نویسندگان
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