کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3108525 | 1192023 | 2009 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Potential Uses of Hemoglobin-based Oxygen Carriers in Critical Care Medicine
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
مراقبت های ویژه و مراقبتهای ویژه پزشکی
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چکیده انگلیسی
Hemoglobin-based oxygen carriers (HBOCs) were initially developed to provide an alternative to blood transfusion. With the realization that hemoglobin solutions not only are red blood cell substitutes but also have a number of additional properties, including hemodynamic effects related to their oncotic and nitric oxide–scavenging effects, the broader concept of “hemoglobin therapeutics” was born. Promising effects on oxygen transport and the microcirculation need to be confirmed, and the results of studies with newer, second-generation HBOCs are eagerly awaited. In the meantime, possible adverse effects need to be carefully evaluated before HBOCs can be widely used in the ICU, emergency room, or prehospital setting.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Care Clinics - Volume 25, Issue 2, April 2009, Pages 311–324
Journal: Critical Care Clinics - Volume 25, Issue 2, April 2009, Pages 311–324
نویسندگان
Jacques Creteur, Jean-Louis Vincent,