کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3112952 | 1192346 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
NeumonÃa adquirida en la comunidad: variantes génicas implicadas en la inflamación sistémicamación sistémica
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
مراقبت های ویژه و مراقبتهای ویژه پزشکی
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چکیده انگلیسی
The inflammatory response depends on several factors, including pathogenicity and duration of the stimulus, and also on the balance between inflammatory and antiinflammatory response. Several studies have presented evidence of the importance of genetic factors in severe infections. The innate immune response prevents the invasion and spread of pathogens during the first hours after infection. Each of the different processes involved in innate immunity may be affected by genetic polymorphisms, which can result in susceptibility or resistance to infection. The results obtained in the different studies do not irrefutably prove the role or function of a gene in the pathogenesis of respiratory infections. However, they can generate new hypotheses, suggest new candidate genes based on their role in the inflammatory response, and constitute a first step in understanding the underlying genetic factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medicina Intensiva - Volume 38, Issue 5, JuneâJuly 2014, Pages 315-323
Journal: Medicina Intensiva - Volume 38, Issue 5, JuneâJuly 2014, Pages 315-323
نویسندگان
J.M. Ferrer Agüero, S. Millán, F. RodrÃguez de Castro, I. MartÃn-Loeches, J. Solé Violán,