کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3144282 1196862 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mandibular distraction osteogenesis enhanced by bone marrow mesenchymal stem cells in rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Mandibular distraction osteogenesis enhanced by bone marrow mesenchymal stem cells in rats
چکیده انگلیسی

SummaryObjectiveThis study was to observe the effects of bone marrow mesenchymal stem cell transplantation on new bone formation in a rat mandibular osteodistraction model.Material and methodsAutologous bone marrow stem cells were obtained from tibiae of 40 male rats. Two weeks after cell harvest, the rats underwent right mandibular distraction and were then randomly divided into two groups (group A=20, group B=20). After distraction was complete, the stem cells were injected into the distracted gaps in group A, while the rats in group B only received physiological saline. Twenty rats (10 from each group) were sacrificed on postoperative days 27 and 55, respectively. The distracted mandibles were harvested and processed for radiographic, histological and histomorphometric analysis.ResultsThe radiodensity of the distraction zone was higher in group A than in group B at both time points. Histologically callus was found in both groups but more bone was formed in group A. Histomorphometric analysis also demonstrated that both new bone volume and thickness of the new trabeculae were significantly greater in group A than in group B.ConclusionThe results of this study suggest that autologous bone marrow stem cell transplantation may be considered as a potential method to accelerate bone regeneration in the distraction gap, and enhance consolidation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cranio-Maxillofacial Surgery - Volume 34, Issue 5, July 2006, Pages 283–289
نویسندگان
, , , , ,