کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3163763 1586252 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunological and clinical significance of HLA class I antigen processing machinery component defects in malignant cells
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Immunological and clinical significance of HLA class I antigen processing machinery component defects in malignant cells
چکیده انگلیسی


• Tumor cell antigenicity is progressively edited by the host’s immune system.
• Downregulation of antigen presentation allows tumors to evade immune rejection.
• Tumor antigen presentation abnormalities are associated with poor clinical outcome.

SummaryExperimental as well as clinical studies demonstrate that the immune system plays a major role in controlling generation and progression of tumors. The cancer immunoediting theory supports the notion that tumor cell immunogenicity is dynamically shaped by the immune system, as it eliminates immunogenic tumor cells in the early stage of the disease and then edits their antigenicity. The end result is the generation of a tumor cell population able to escape from immune recognition and elimination by tumor infiltrating lymphocytes. Two major mechanisms, which affect the target cells and the effector phase of the immune response, play a crucial role in the editing process. One is represented by the downregulation of tumor antigen (TA) processing and presentation because of abnormalities in the HLA class I antigen processing machinery (APM). The other one is represented by the anergy of effector immune infiltrates in the tumor microenvironment caused by aberrant inhibitory signals triggered by immune checkpoint receptor (ICR) ligands, such as programmed death ligand-1 (PD-L1). In this review, we will focus on tumor immune escape mechanisms caused by defects in HLA class I APM component expression and/or function in different types of cancer, with emphasis on head and neck cancer (HNC). We will also discuss the immunological implications and clinical relevance of these HLA class I APM abnormalities. Finally, we will describe strategies to counteract defective TA presentation with the expectation that they will enhance tumor recognition and elimination by tumor infiltrating effector T cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 58, July 2016, Pages 52–58
نویسندگان
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