کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3163773 1586256 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Could the biological robustness of low level laser therapy (Photobiomodulation) impact its use in the management of mucositis in head and neck cancer patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Could the biological robustness of low level laser therapy (Photobiomodulation) impact its use in the management of mucositis in head and neck cancer patients
چکیده انگلیسی


• Low level laser therapy (LLLT) appears to be efficacious in managing radiation-induced oral mucositis.
• LLLT is biologically robust.
• LLLT-activated pathways have been associated with negative tumor outcomes including proliferation, invasion, angiogenesis, metastases and cancer-treatment resistance.
• An investigational strategy to assure that LLLT’s anti-mucositis efficacy is independent of its potential to enhance threatening tumor behavior is noted.

SummaryLow level laser therapy (LLLT) has been noted to be effective in mitigating the development of oral mucositis among patients being treated with chemoradiation for cancers of the head and neck. To explain the biological basis for this observation we performed a comprehensive literature search. Our investigation identified a substantial number of LLLT-activated pathways that have been strongly associated with negative tumor outcomes including proliferation, invasion, angiogenesis, metastases and cancer-treatment resistance. In light of these findings, we suggest an investigational strategy to assure that LLLT’s anti-mucositis efficacy is independent of its possible potential to enhance threatening tumor behaviors. Included are appropriate pre-clinical modeling, short- and long-term follow-up of LLLT-treated patients, and the requirement for consistency of LLLT parameters.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 54, March 2016, Pages 7–14
نویسندگان
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