کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3163802 | 1198745 | 2015 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer](/preview/png/3163802.png)
• p16 IHC has a 92% concordance with high risk HPV oropharyngeal squamous cancer.
• ROCHE linear array test identifies additional high risk HPV cancers that are p16 positive.
• HPV16 accounts for 92% of HR HPV oropharyngeal cancer.
• HPV racial disparity in incidence and survival in Blacks and Whites.
• Overall survival by HPV and p16 status.
SummaryObjectivesExamine the effect of concordance between p16 overexpression and HR (high risk) HPV DNA status on overall survival in a large series of oropharyngeal squamous cell carcinoma (OPSCC) cases.Materials and methodsA total of 185 patients with primary OPSCC had genomic DNA tested by PCR for the HPV16 E6 and E7 oncogenes. 184 of 185 patients had p16 IHC performed. Linear array HPV genotyping was performed in all 21 HPV16/p16 discordant cases (HPV16+/p16− or HPV16−/p16+) as well as in 43 control cases.Results73 of 185 patients were positive for HR HPV (39%). Six of 73 HPV infections were due to HR HPV types other than HPV16: types 31 (1), 33 (2), 51 (1), 58 (1), and 59 (1); all 6 cases were p16 positive. p16 IHC was concordant with HR HPV testing in 169 of 184 cases (92%), and had a sensitivity and specificity of 92% and 92%. HR HPV+/p16+ and discordant HR HPV/p16 patients had significantly improved overall survival compared to HR HPV−/p16− patients.Conclusionp16 IHC is a reliable surrogate marker for HR HPV testing in OPSCC. Prognostically favorable HR HPV genotypes other than HPV16 are reflected in p16 positivity.
Journal: Oral Oncology - Volume 51, Issue 9, September 2015, Pages 862–869