کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3164010 | 1198763 | 2014 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Fentanyl pectin nasal spray as treatment for incident predictable breakthrough pain (BTP) in oral mucositis induced by chemoradiotherapy in head and neck cancer Fentanyl pectin nasal spray as treatment for incident predictable breakthrough pain (BTP) in oral mucositis induced by chemoradiotherapy in head and neck cancer](/preview/png/3164010.png)
SummaryBackgroundPainful mucositis is one of the most distressing toxicities of chemoradiotherapy (CRT) for head and neck cancer (HNC), with the characteristics of incidental predictable breakthrough pain (BTP) during swallowing. Fentanyl pectin nasal spray (FPNS) could be a good therapeutic option.MethodsPatients were prospectively considered if receiving basal analgesic therapy with opiates for painful mucositis of grade ⩾4 on a numerical rating scale from 0 to 10. They were offered FPNS 100 mcg before oral intake. When patients reached the effective dose, they evaluated the basal pain intensity before FPNS use and after 10, 20, 30 and 40 min.ResultsSeventeen HNC patients were offered FPNS before oral intake, with 15 patients completing treatment. Mean reduction of incidental BTP intensity after FPNS was 3.1 points (range 1.2–5.8). Mean time elapsed since FPNS use and highest pain reduction was 26 min.ConclusionsFPNS demonstrated activity against BTP when swallowing in HNC patients. These data should be considered as hypothesis-generating.
Journal: Oral Oncology - Volume 50, Issue 9, September 2014, Pages 884–887