کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3164158 1198770 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recurrence patterns and management of oral cavity premalignant lesions
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Recurrence patterns and management of oral cavity premalignant lesions
چکیده انگلیسی

SummaryObjectiveTo gain an understanding of head and neck mucosal premalignant recurrence and progression based on histology, treatment modality, and risk factors.DesignRetrospective chart review.SettingAcademic medical center.PatientsPatients who were followed or treated for oral cavity dysplasia/carcinoma in situ.Main outcomes measuresComparisons with clinical features, degree of dysplasia, anatomical location, rate of recurrences as well as malignant transformation and overall outcome were made.ResultsOf the 136 patients who were included in the study, 20% (n = 27) initially presented with mild dysplasia, 39% (n = 53) with moderate dysplasia, 21% (n = 29) with severe dysplasia, and 20% (n = 27) with carcinoma in situ. Wide local excision (HR 0.54, p = 0.05) was associated with reduced local recurrence in comparison to observation. In comparison to observation, both wide local excision (HR 0.43, p = 0.04) and CO2/NO Yag laser treatment (HR 0.14, p = 0.02) of dysplastic lesions significantly reduced progression to cancer. Management of mild dysplasia included observation (n = 13), excision (n = 10) and laser therapy (n = 3). Six of the 13 observed patients suffered a premalignancy recurrence, whereas only 4 of the 13 patients who underwent excision/laser treatment experienced a recurrence. Similarly, 5/13 observed patients eventually progressed to malignancy in comparison to only 2/13 patients who underwent initial excision/laser treatment.ConclusionWide excision and/or ablation of head and neck mucosal premalignancy is more effective than observation in preventing recurrence of premalignancy and progression to malignancy. Mild dysplasia has a potentially high rate of recurrence and progression to malignancy when observed, and may be treated by wide excision or ablation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 49, Issue 8, August 2013, Pages 814–817
نویسندگان
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