کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3164427 | 1198790 | 2012 | 6 صفحه PDF | دانلود رایگان |
SummaryPatients with pT1cN0 oral squamous cell carcinomas (OSCC) are generally not treated with a neck dissection (ND). However, in 25% of cN0 patients, nodal metastases become apparent during follow-up. Infiltration depth of the primary tumour has been consistently associated with the presence of nodal metastasis, but proposed cut-off depths for performing a ND vary considerably. The aim of this study was to explore the infiltration depth as predictor for the nodal status and to recommend a cut-off depth for performing a ND.From our database of 351 primary oral carcinomas, we selected all pT1–2 tumours (n = 246). Infiltration depth was measured in 212 cases. Neck status was determined by histopathological examination of the dissection specimen, or by at least two years of follow-up.Mean infiltration depth was 5.49 mm (95% CI: 4.86–6.12) in the N0 and 8.40 mm (95% CI: 7.38–9.43) in the N+ group (p < 0.001). cN status, lymphovascular invasion and infiltration depth were the only independent predictors for nodal status in multiple logistic regression. ROC-analysis on pT1cN0 tumours resulted in an optimal cut-off for the prediction of the nodal status at a depth of 4.59 mm. This cut-off identified a subgroup of patients at increased risk for nodal metastasis (OR = 8.3) and with significantly shorter survival.Tumour infiltration depth is an independent predictor for nodal status in pT1–2 OSCC. In pT1cN0 tumours, a cut-off at 4.59 mm results in the best predictive value.We recommend an infiltration depth of ⩾4 mm as an indication to perform a neck dissection in pT1cN0 OSCC.
Journal: Oral Oncology - Volume 48, Issue 4, April 2012, Pages 337–342