کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3165097 | 1198821 | 2009 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma](/preview/png/3165097.png)
SummaryMucoepidermoid carcinoma (MEC) is a relatively uncommon carcinoma of variable histology that can involve many tissue types, most commonly major and minor salivary glands and the tracheo-bronchial tree. In a significant number of cases a recurring t(11;19) translocation with an associated novel fusion oncogene (CRTC1-MAML2) is present. This translocation is also found in Warthin’s tumour and clear cell hidradenoma of the skin. The CRTC1-MAML2 oncogene acts as a transcription factor on Notch and CREB regulatory pathways, disrupting normal cell-cycle and differentiation, contributing to tumour development. Data suggest that in MEC, the presence of CRTC1-MAML2 may have some prognostic value. An understanding of these mechanisms extends our knowledge of the role of fusion oncogenes in epithelial malignancy. A review of CRTC1-MAML2 in MEC is presented.
Journal: Oral Oncology - Volume 45, Issue 1, January 2009, Pages 2–9