کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3165721 | 1198847 | 2007 | 9 صفحه PDF | دانلود رایگان |
SummaryWe report the incidence, risk factor(s), and overall survival (OS) of second/multiple primary tumors (SPTs/MPTs) in oral cavity squamous cell carcinoma (OSCC) patients in betel quid chewing areas. Of 816 untreated OSCC patients who had radical surgery, 15.7% had either synchronous or metachronous SPTs. The SPTs (70.3%) were at the oral cavity. SPTs (18.8%) developed third primary tumors, with a significantly higher incidence in synchromous than metachronous SPTs (p = 0.001). An optimal, but significantly lower, 5-year OS was observed in patients with SPTs/MPTs than without (54.0% vs. 67.2%, p = 0.0195). By multivariate analyses, OSCC sub-sites (p = 0.006) and lymphatic permeation (p = 0.040) were independent risk factors for SPT rate. A significantly higher 5-year OS was observed in SPT patients receiving a second radical surgery at the oral cavity/soft palate than patients that did not (p = 0.0001). A good survival rate can be obtained for OSCC patients with resectable SPTs/MPTs.
Journal: Oral Oncology - Volume 43, Issue 8, September 2007, Pages 811–819