کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3170437 | 1199788 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Evaluation of bone regeneration by porous alpha-tricalcium phosphate/atelocollagen sponge composite in rat calvarial defects Evaluation of bone regeneration by porous alpha-tricalcium phosphate/atelocollagen sponge composite in rat calvarial defects](/preview/png/3170437.png)
PurposeBoth atelocollagen and alpha-tricalcium phosphate (α-TCP) particles are widely applied as bone graft materials. In this study, we combined atelocollagen and porous α-TCP particles to form an α-TCP/atelocollagen composite sponge (α-TCP/CS), and we evaluated its effects on bone regeneration in rat calvarial defects.Materials and methodsα-TCP granules were mixed with a collagen solution. The mixture was poured into plastic molds and then frozen to −80 °C and freeze-dried for 24 h. The composites were then cross-linked in vacuo at 140 °C for 24 h. The obtained composites were characterized by XRD and SEM and observed using micro-CT and histological analysis.ResultsIn vivo micro-CT images at 2, 4, and 6 weeks after surgery showed that in the α-TCP/CS group, the bone volume, bone mineral density, and bone mineral content were higher than those in the groups with only atelocollagen and without scaffolds at 6 weeks after surgery. Histological analysis showed that α-TCP was completely absorbed, and new bone that was continuous along the original bone was observed.ConclusionThis study demonstrated that composite sponges created using porous α-TCP particles and atelocollagen were sufficiently adaptable for treating bone defects.
Journal: Orthodontic Waves - Volume 72, Issue 1, March 2013, Pages 23–29