Profil ekspresji genów kodujÄ cych TGF-β1 i jego receptory TGFβRI, TGFβRII i TGFβRIII w polipach nosa

Considering regulative function of TGFβ1 in inflammation processes, its low concentration in nasal polyps tissue may influence on migration and survival of inflammation cells. The high expression of genes coding TGFβRI, TGF-βRII and TGF-βRIII receptors in all the polyps and healthy tissues, show readiness to transduction of TGFβ. It may suggest that, less intensive TGFβ1 expression in nasal polyps may be connected with the presence of other than first TGFβ isoforms. This problem needs further investigations to set precise role of individual TGFβ isoforms and other growth factors in the pathogenesis of NSP as their interactions with local cytokines. It may help to work out more effective and specific therapeutic methods in nasal polyps therapy.