کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3177736 1200313 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
S100B and NSE serum levels in obstructive sleep apnea syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
S100B and NSE serum levels in obstructive sleep apnea syndrome
چکیده انگلیسی

Background and purposeObstructive sleep apnea syndrome (OSAS) is a chronic disease ranging from innocuous to life-threatening and causes brain alterations manifested by neuropsychiatric symptoms. Neuron-specific enolase (NSE) and the astrocytic protein S100B are established sensitive peripheral biochemical markers of brain injury. In the present work we measured the serum levels of S100B and NSE in order to evaluate the deleterious effects of OSAS to the brain.Patients and methodsWe studied 29 male patients with OSAS and 17 male asymptomatic control subjects with an apnea–hypopnea index (AHI) less than five events per hour. Patients and control subjects were evaluated by full-night polysomnography (PSG) and by Mini International Neuropsychiatric Interview (MINI) for the presence of neuropsychiatric symptoms. In the morning following the PSG, blood was collected and serum levels of S100B and NSE were measured using standard techniques.ResultsThe AHI in the OSAS group was (mean±SD) 27±25 AH/h, ranging from 5 to 99 AH/h. S100B was higher in OSAS (0.15±0.09 μg/l) than in the control group (0.08±0.06 μg/l; P<0.01). Serum NSE was similar in both groups (17.5±12.2 vs. 15.8±6.8 ng/ml).ConclusionsWe report elevated serum S100B levels in OSAS patients in this study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sleep Medicine - Volume 7, Issue 5, August 2006, Pages 431–435
نویسندگان
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