کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3178058 | 1200324 | 2008 | 6 صفحه PDF | دانلود رایگان |

BackgroundObstructive sleep apnea (OSA) has been associated with increased systemic inflammatory responses that may contribute to an increased risk for end-organ morbidity. The changes in levels of pro-inflammatory cytokine IL-6 , and the anti-inflammatory cytokine IL-10, both of which play a major role in atherogenesis, a major consequence of OSA, have not specifically been assessed in pediatric patients.MethodsConsecutive non-obese children (aged 4–9 years) who were polysomnographically diagnosed with OSA, and age-, gender-, ethnicity-, and BMI-matched control children underwent a blood draw the next morning after a sleep study and plasma samples were assayed for interleukins 6 (IL-6) and 10 (IL-10). These tests were repeated 4–6 months after tonsillectomy and adenoidectomy (T&A) in children with OSA.ResultsIL-6 levels were higher and IL-10 plasma levels were lower in children with OSA and returned to control levels after T&A.ConclusionsSystemic inflammation is a constitutive component and consequence of OSA in many children, even in the absence of obesity, and is reversible upon treatment in most patients.
Journal: Sleep Medicine - Volume 9, Issue 3, March 2008, Pages 254–259