کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3178396 1200358 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of methylphenidate on the sleep-wake cycle of brain-injured patients undergoing rehabilitation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
The effect of methylphenidate on the sleep-wake cycle of brain-injured patients undergoing rehabilitation
چکیده انگلیسی

Background and purposeA number of neurostimulants are routinely used as part of post-acute care of hospitalized brain-injured patients. To our knowledge, the effect of these stimulants on the sleep–wake cycles of brain-injured patients undergoing rehabilitation has not been addressed. We examined the effect of one of the most commonly used neurostimulants, methylphenidate, on the sleep–wake behavior of brain-injured patients undergoing rehabilitation at a dedicated brain injury clinic.Patients and methodFor this study, records of patients admitted between January and December 1999 were scrutinized retrospectively for the data on observationally defined sleep–wake distribution. A total of 30 patients diagnosed with traumatic brain injury were identified as having been observed for a full 24 h a day for at least 10 days. Some of these patients (n=17) were administered methylphenidate on clinical grounds. They served as the experimental group, while the unmedicated patients (n=13) served as controls. For the present analysis, the sleep–wake cycles were arbitrarily designated as nighttime and daytime, respectively. A cumulative sleep–wake quantity in a 24-h period was also observed.ResultThe average number of hours of sleep during a 24-h period was not significantly different for the two cohorts. Similar trends emerged for the nighttime and daytime observations. On the whole, methylphenidate appears not to have unfavorable effects on sleep–wake cycles, presently defined as nighttime, daytime and 24-h, in the traumatic brain injury population.ConclusionThis study sought to gain better understanding of the effect of methylphenidate on daytime sleepiness and nighttime sleep, and the data suggest that administration of methylphenidate does not appear to have an adverse effect on sleep–wake quantity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sleep Medicine - Volume 7, Issue 3, April 2006, Pages 287–291
نویسندگان
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