کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
318975 539195 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression
چکیده انگلیسی

Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is a promising candidate in the investigation of the clinical phenotype of “anxious depression”.Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. Additionally, NPY gene impact on amygdala activation during facial emotion processing was analyzed in a subsample of 35 depressed patients.Particularly in anxious depression, the less active NPY rs16147 −399C allele conferred slow response after 2 weeks and failure to achieve remission after four weeks of treatment. The rs16147 C allele was further associated with stronger bilateral amygdala activation in response to threatening faces in an allele-dose fashion.The present results point towards a possible influence of functional NPY gene variation on antidepressant treatment response in anxious depression, potentially conveyed by altered emotional processing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 20, Issue 5, May 2010, Pages 301–309
نویسندگان
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