کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
319118 | 539231 | 2008 | 6 صفحه PDF | دانلود رایگان |
Intra-nasally instilled benzodiazepines have been proposed for acute anxiety episodes. However, routes with faster absorption may increase abuse liability. This study compared abuse liability of intra-nasal midazolam between subjects with a history of intra-nasal drug abuse and non-psychiatric subjects on a single-blind randomized controlled trial. Thirty-one inhaled-cocaine abusers and 34 normal volunteers received either 1 mg intra-nasal midazolam or active placebo. Visual analogue scales assessing desire to repeat the experience (ER) and Experience Liking (EL) assessed abuse liability. Profile analysis for repeated measures showed a significant effect of time over ER (F[5,57] = 3.311, p = 0.011) and EL (F[5,57] = 3.947, p = 0.004), diagnostic group (cocaine abusers scoring higher on both — F[5,57] = 5.229, p = 0.026; F[5,57] = 4.946, p = 0.030), regardless of the administered substance. It is concluded that the intra-nasal route does not seem to pose risks for non-psychiatric individuals, but it may represent a risk in itself for subjects with a history of drug abuse through this path.
Journal: European Neuropsychopharmacology - Volume 18, Issue 10, October 2008, Pages 723–728