کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
319256 | 539261 | 2006 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Visualization of the cortical dopamine transporter in type 1 and 2 alcoholics with human whole hemisphere autoradiography Visualization of the cortical dopamine transporter in type 1 and 2 alcoholics with human whole hemisphere autoradiography](/preview/png/319256.png)
We measured cortical dopamine transporter (DAT) in Cloninger type 1 and 2 alcoholics by using [125I]PE2I as a radioligand in human postmortem whole hemispheric autoradiography, and evaluated the putative correlations of DAT between cortical areas and nucleus accumbens. There was a low, but distinct cortical binding in the cryosections. The mean binding was generally higher in both groups of alcoholics compared to controls, and the results reached statistical significance with a large effect size (1.25) in the temporal cortex of type 2 alcoholics. This is surprising, because several studies have reported lower DAT densities in the striatum among alcoholics compared to controls. Moreover, the density of DAT had a statistically significant positive correlation between temporal cortex and nucleus accumbens in controls, whereas among type 2 alcoholics the correlation was statistically significantly negative, which may suggest some pathology relating to the antisocial behaviour of these alcoholics.
Journal: European Neuropsychopharmacology - Volume 16, Issue 8, December 2006, Pages 552–560