کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
319887 539608 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The dopamine agonist apomorphine differentially affects cognitive performance in alcohol dependent patients and healthy controls
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
The dopamine agonist apomorphine differentially affects cognitive performance in alcohol dependent patients and healthy controls
چکیده انگلیسی

BackgroundReduced metabolic activity in frontal brain regions, and reduced striatal dopamine receptor densities have been shown in alcohol dependent patients. Little is known on functional changes in the fronto-striatal-thalamic dopaminergic neurocircuitry in these patients. The objective of this study was to assess sensitivity of prefrontal dopamine receptors in alcohol dependent patients.Experimental proceduresMale alcohol dependent patients (N = 40) and healthy controls (N = 39) performed an AX-continuous performance test before and after administration of the DA agonist apomorphine (0.005 mg/kg).ResultsAt baseline alcohol dependent patients were slower and less accurate compared to healthy controls. After administration of apomorphine, performance improved in alcohol dependent patients and deteriorated in healthy controls.ConclusionsReduced cognitive performance in alcohol dependent patients compared with healthy controls may indicate dopamine dysfunctioning at the prefrontal level. Improvement of cognitive performance in alcohol dependent patients after administration of apomorphine and deterioration in healthy controls provides evidence for an inverted U-shape relation between dopaminergic functioning and cognitive performance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 19, Issue 1, January 2009, Pages 68–73
نویسندگان
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