کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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319906 | 539618 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The effect of DHEA complementary treatment on heroin addicts participating in a rehabilitation program: A preliminary study The effect of DHEA complementary treatment on heroin addicts participating in a rehabilitation program: A preliminary study](/preview/png/319906.png)
We evaluated the effect of DHEA complementary treatment in opiate addicts undergoing detoxification. DHEA (100 mg/day) or placebo was added to the routine medication protocol in a randomized, double blind controlled study. Follow-up for 12 months was conducted. Two separate DHEA-treated subgroups were identified by the Fuzzy clustering method: one showed statistically significant improvement in the severity of withdrawal symptoms, depression and anxiety scores (n = 34; p < 0.001 for all) and the other subgroup deteriorated in all measures (n = 15). DHEA at the end of the detoxification program showed a tendency towards correlation with the duration of abstinence (r = 0.6843; p > 0.05; n = 6), while a negative correlation was obtained with the cortisol level (r = − 0.900; p = 0.005, n = 8). The completion-rate of the DHEA-improved subgroup was greater than in the DHEA-deteriorated subgroup (64.7% vs. 33.3%, respectively).The influence of supplementary DHEA treatment was mostly effective in heroin addicts who had not previously used either cocaine or benzodiazepines and who had experienced only few withdrawal programs.
Journal: European Neuropsychopharmacology - Volume 18, Issue 6, June 2008, Pages 406–413