کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
319906 539618 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of DHEA complementary treatment on heroin addicts participating in a rehabilitation program: A preliminary study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
The effect of DHEA complementary treatment on heroin addicts participating in a rehabilitation program: A preliminary study
چکیده انگلیسی

We evaluated the effect of DHEA complementary treatment in opiate addicts undergoing detoxification. DHEA (100 mg/day) or placebo was added to the routine medication protocol in a randomized, double blind controlled study. Follow-up for 12 months was conducted. Two separate DHEA-treated subgroups were identified by the Fuzzy clustering method: one showed statistically significant improvement in the severity of withdrawal symptoms, depression and anxiety scores (n = 34; p < 0.001 for all) and the other subgroup deteriorated in all measures (n = 15). DHEA at the end of the detoxification program showed a tendency towards correlation with the duration of abstinence (r = 0.6843; p > 0.05; n = 6), while a negative correlation was obtained with the cortisol level (r = − 0.900; p = 0.005, n = 8). The completion-rate of the DHEA-improved subgroup was greater than in the DHEA-deteriorated subgroup (64.7% vs. 33.3%, respectively).The influence of supplementary DHEA treatment was mostly effective in heroin addicts who had not previously used either cocaine or benzodiazepines and who had experienced only few withdrawal programs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 18, Issue 6, June 2008, Pages 406–413
نویسندگان
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