کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
319953 539638 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum creatine kinase level in unmedicated nonpsychotic, psychotic, bipolar and schizoaffective depressed patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Serum creatine kinase level in unmedicated nonpsychotic, psychotic, bipolar and schizoaffective depressed patients
چکیده انگلیسی

Creatine kinase (CK) level was previously found to be increased in the majority of hospitalized acute psychotic patients.We aimed to asses the possible differences in CK level in various forms of depression: major with and without psychotic symptoms, of bipolar depression and schizoaffective depression.Unmedicated hospitalized patients participated: nonpsychotic major depression (n = 39), psychotic major depression (n = 23), bipolar depression (n = 23) and schizoaffective depression (n = 24). The severity of depression was assessed by the Hamilton Depression Rating Scale (Ham-D) and blood samples were collected in the morning of admission day, prior to any treatment.Ham-D yielded a significantly higher score for psychotic major depression group, compared with all other groups which showed similar score. CK serum level was significantly higher in nonpsychotic major depression than in all other forms of depression.The results indicate a biological difference between the nonpsychotic major depression and the “psychotic” cluster of depressive syndromes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 17, Issue 3, February 2007, Pages 194–198
نویسندگان
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