کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
320088 539661 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dual monoamine modulation for the antidepressant-like effect of lamotrigine in the modified forced swimming test
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Dual monoamine modulation for the antidepressant-like effect of lamotrigine in the modified forced swimming test
چکیده انگلیسی

Lamotrigine is an anticonvulsant drug that exhibits a clinical antidepressant effect. However, few studies have been conducted with lamotrigine in animal models of depression and its mechanism of antidepressant action is still unclear. The present study evaluates the effect of lamotrigine (5–20 mg/kg, i.p.) in the modified forced swimming test and compare its behavior pattern in the test with those of paroxetine (20 mg/kg, i.p.), nortriptyline (20 mg/kg, i.p.) and dizolcipine–MK-801 (0.1 mg/kg, i.p.). The effect of lamotrigine on locomotor activity and memory was also studied in order to exclude false-positive results. At low doses, lamotrigine (10 mg/kg) decreased immobility and increased climbing scores, a similar pattern to nortriptyline. A higher lamotrigine dose (20 mg/kg) also increased swimming scores. Lamotrigine neither changed locomotion in the open-field test nor impaired habituation. Paroxetine and dizolcipine decreased immobility and increased swimming. Dizolcipine also decreased climbing. However, although the effects of paroxetine and nortriptyline were seen without effect on locomotor activity, dizolcipine increased locomotor activity. The present study indicates that the antidepressant-like effect of lamotrigine is probably related to noradrenergic/serotonergic systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 16, Issue 6, August 2006, Pages 451–458
نویسندگان
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