کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
320108 539663 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
No effect of oral l-tryptophan or alpha-lactalbumin on total tryptophan levels in breast milk
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
No effect of oral l-tryptophan or alpha-lactalbumin on total tryptophan levels in breast milk
چکیده انگلیسی

Postpartum depression (PPD) is the most common complication of childbearing with a 13% prevalence rate. Sleep disturbances are also common, particularly during early postpartum. In theory, l-tryptophan could improve sleep and reduce depressed mood in early postpartum; however, the first step in clinical development of tryptophan for use in postpartum is to measure the effect of oral l-tryptophan on its concentrations in breast milk, which is presently unknown.The aims were to investigate the effect of oral l-tryptophan and alpha-lactalbumin, a protein with high tryptophan concentration, on total and free tryptophan levels in breast milk and plasma, and to compare free tryptophan levels in breast milk with those in common infant formulas.Thirty healthy breastfeeding women were randomly allocated to receive 2 g or 4 g of l-tryptophan, or, 20 g or 40 g of alpha-lactalbumin or no supplement. Free tryptophan levels were also measured in 12 different infant formulas.Total tryptophan in breast milk was unaffected by oral administration of l-tryptophan or alpha-lactalbumin (repeated measures of ANOVA (rANOVA), group effect: p=0.93). Both l-tryptophan and alpha-lactalbumin were associated with greater free tryptophan levels in breast milk (rANOVA, group effect: p<0.001) (representing 2% of total tryptophan), but these concentrations were within the range of commonly used infant formulas.In contrast to most sleep inducing medications, l-tryptophan does not affect its total concentration in breast milk. These results support further investigation of dietary l-tryptophan and alpha-lactalbumin as part of a dietary supplementation approach to address sleep disturbances in postpartum and reduce risk of PPD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 25, Issue 6, June 2015, Pages 779–787
نویسندگان
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