کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
321411 539799 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced platelet vesicular monoamine transporter density in Tourette's syndrome pediatric male patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Reduced platelet vesicular monoamine transporter density in Tourette's syndrome pediatric male patients
چکیده انگلیسی

The vesicular monoamine transporter (VMAT2) plays a major role in the synaptic accumulation and quantal release of monoamines. In this study, we assessed high affinity [3H]dihydrotetrabenazine binding to platelet VMAT2, in a group of untreated male Tourette's syndrome (TS) patients (age: 8–17.5 years, n = 9) and in a group of age- and sex-matched healthy controls (age: 9–16 years, n = 16). Significantly decreased platelet VMAT2 density (Bmax) (− 23%, p = 0.016) was observed in the TS patients. The affinity (Kd) of the ligand to platelet VMAT2 was similar in both groups. If the lower platelet VMAT2 density also occurred in the brain, it may have serve as an adaptive mechanism geared to decrease dopamine storage in the presynaptic neurons and thereby to attenuate the dopaminergic overactivity and ameliorate the movement disorder.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 17, Issue 8, July 2007, Pages 523–526
نویسندگان
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