کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
321695 | 539814 | 2006 | 6 صفحه PDF | دانلود رایگان |

This study concerned effects of vitamin E and the cholinergic system on memory retention of passive avoidance learning in rats. Post-training intracerebroventricular (i.c.v.) injections were carried out in all experiments. Administrations of vitamin E (10, 25 and 50 μg/rat), nicotine (0.1 μg/rat) and pilocarpine (0.5 μg/rat), the muscarinic receptor agonist increased memory retention, while mecamylamine (0.01, 0.1 and 0.5 μg/rat), the nicotinic receptor antagonist and scopolamine (0.1, 1 and 5 μg/rat), the muscarinic receptor antagonist decreased memory retention. The combination of vitamin E with nicotine or pilocarpine showed potentiation. Effects of mecamylamine or scopolamine were attenuated by vitamin E. It is concluded that vitamin E has a close interaction with cholinergic system in memory retention process.
Journal: European Neuropsychopharmacology - Volume 16, Issue 2, February 2006, Pages 101–106